A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

Wonhwa Lee; Junyoung Seo; Soyoung Kwak; Eun Ji Park; Dong Hee Na; Soyoun Kim; You Mie Lee; In San Kim; Jong Sup Bae

doi:10.1002/adma.201503093

A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

Wonhwa Lee
, Junyoung Seo
, Soyoung Kwak
, Eun Ji Park
, Dong Hee Na
, Soyoun Kim
, You Mie Lee
, In San Kim
, Jong Sup Bae

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.

Original language	English
Pages (from-to)	6637-6643
Number of pages	7
Journal	Advanced Materials
Volume	27
Issue number	42
DOIs	https://doi.org/10.1002/adma.201503093
State	Published - 1 Nov 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ferritin
nanoparticles
PC-gla
sepsis
TRAP

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10.1002/adma.201503093

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title = "A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment",

abstract = "New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.",

keywords = "ferritin, nanoparticles, PC-gla, sepsis, TRAP",

author = "Wonhwa Lee and Junyoung Seo and Soyoung Kwak and Park, \{Eun Ji\} and Na, \{Dong Hee\} and Soyoun Kim and Lee, \{You Mie\} and Kim, \{In San\} and Bae, \{Jong Sup\}",

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month = nov,

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doi = "10.1002/adma.201503093",

language = "English",

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T1 - A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

AU - Lee, Wonhwa

AU - Seo, Junyoung

AU - Kwak, Soyoung

AU - Park, Eun Ji

AU - Na, Dong Hee

AU - Kim, Soyoun

AU - Lee, You Mie

AU - Kim, In San

AU - Bae, Jong Sup

PY - 2015/11/1

Y1 - 2015/11/1

N2 - New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.

AB - New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.

KW - ferritin

KW - nanoparticles

KW - PC-gla

KW - sepsis

KW - TRAP

UR - https://www.scopus.com/pages/publications/84946763409

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DO - 10.1002/adma.201503093

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AN - SCOPUS:84946763409

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JO - Advanced Materials

JF - Advanced Materials

IS - 42

ER -

A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment

Abstract

UN SDGs

Keywords

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