TY - GEN
T1 - A coronary drug-eluting stent functionalized with magnesium hydroxide on abluminal layer for improving re-endothelialization with a minimalized inflammatory response
AU - Park, Wooram
AU - Jeong, Da Won
AU - Han, Dong Keun
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: The drug-eluting coronary stent (DES) has been widely utilized to overcome the problem of restenosis by controlled drug release from the polymer-coating layer.1 However, the conventional DES still induces restenosis and late thrombosis because of incomplete re-endothelialization and undesired inflammation. Notably, the inflammatory response is caused by an acidic environment resulting from byproducts of coated biodegradable polymers. To overcome the limitation, we developed a DES coated only on the abluminal side with magnesium hydroxide (MH) that can improve re-endothelialization and prevent an inflammatory reaction by neutralizing the acidic degradation products.2
AB - Statement of Purpose: The drug-eluting coronary stent (DES) has been widely utilized to overcome the problem of restenosis by controlled drug release from the polymer-coating layer.1 However, the conventional DES still induces restenosis and late thrombosis because of incomplete re-endothelialization and undesired inflammation. Notably, the inflammatory response is caused by an acidic environment resulting from byproducts of coated biodegradable polymers. To overcome the limitation, we developed a DES coated only on the abluminal side with magnesium hydroxide (MH) that can improve re-endothelialization and prevent an inflammatory reaction by neutralizing the acidic degradation products.2
UR - https://www.scopus.com/pages/publications/85065435717
M3 - Conference contribution
AN - SCOPUS:85065435717
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 468
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -