A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men

Sung Keun Park; Hyejin Chun; Jae Hong Ryoo; Sang Wha Lee; Hong Soo Lee; Kyung Won Shim; Choo Yon Cho; Dong Ryeol Ryu; Taeg Su Ko; Eugene Kim; Se Jin Park; Jai Hyung Park; Seok Jin Hong; Hyun Pyo Hong

doi:10.1016/j.cca.2015.03.043

A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men

Sung Keun Park
, Hyejin Chun
, Jae Hong Ryoo
, Sang Wha Lee
, Hong Soo Lee
, Kyung Won Shim
, Choo Yon Cho
, Dong Ryeol Ryu
, Taeg Su Ko
, Eugene Kim
, Se Jin Park
, Jai Hyung Park
, Seok Jin Hong
, Hyun Pyo Hong

Department of Orthopedic Surgery

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Despite the previous studies showing the relationship between microalbuminuria and insulin resistance, longitudinal effect of insulin resistance on development of microalbuminuria is not clearly identified in non-diabetic population. Methods: One thousand six hundred three non-diabetic Korean men without microalbuminuria in 2005 had been followed up for the development of microalbuminuria until 2010. Microalbuminuria was evaluated by urine-albumin creatinine ration, and insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Cox proportional hazards model was used to estimate the risk for microalbuminuria according to the tertile of HOMA-IR. Results: During 5465.8 person-y of average follow-up, microalbuminuria developed in 76 (4.7%) participants. Incidence of microalbuminuria increased in proportion to the level of HOMA-IR (tertile 1: 3.0%, tertile 2: 4.1%, tertile 3: 7.1%, P<. 0.001). When the 1st tertile of HOMA-IR was set as reference, hazard ratios and 95% confidence interval were 1.15 (0.56-2.35) and 2.07 (1.05-4.09) for those in the 2nd and 3rd tertiles of HOMA-IR, even after adjusting multiple covariates, respectively (. P for linear trend. =. 0.054). Conclusions: Increased insulin resistance was a predictor of microalbuminuria in Korean men.

Original language	English
Pages (from-to)	111-116
Number of pages	6
Journal	Clinica Chimica Acta
Volume	446
DOIs	https://doi.org/10.1016/j.cca.2015.03.043
State	Published - 5 Jun 2015

Keywords

HOMA-IR
Insulin resistance
Microalbuminuria

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10.1016/j.cca.2015.03.043

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@article{cdfd0c666f5c4e3dae4cc0181b0f21c9,

title = "A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men",

abstract = "Background: Despite the previous studies showing the relationship between microalbuminuria and insulin resistance, longitudinal effect of insulin resistance on development of microalbuminuria is not clearly identified in non-diabetic population. Methods: One thousand six hundred three non-diabetic Korean men without microalbuminuria in 2005 had been followed up for the development of microalbuminuria until 2010. Microalbuminuria was evaluated by urine-albumin creatinine ration, and insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Cox proportional hazards model was used to estimate the risk for microalbuminuria according to the tertile of HOMA-IR. Results: During 5465.8 person-y of average follow-up, microalbuminuria developed in 76 (4.7\%) participants. Incidence of microalbuminuria increased in proportion to the level of HOMA-IR (tertile 1: 3.0\%, tertile 2: 4.1\%, tertile 3: 7.1\%, P<. 0.001). When the 1st tertile of HOMA-IR was set as reference, hazard ratios and 95\% confidence interval were 1.15 (0.56-2.35) and 2.07 (1.05-4.09) for those in the 2nd and 3rd tertiles of HOMA-IR, even after adjusting multiple covariates, respectively (. P for linear trend. =. 0.054). Conclusions: Increased insulin resistance was a predictor of microalbuminuria in Korean men.",

keywords = "HOMA-IR, Insulin resistance, Microalbuminuria",

author = "Park, \{Sung Keun\} and Hyejin Chun and Ryoo, \{Jae Hong\} and Lee, \{Sang Wha\} and Lee, \{Hong Soo\} and Shim, \{Kyung Won\} and Cho, \{Choo Yon\} and Ryu, \{Dong Ryeol\} and Ko, \{Taeg Su\} and Eugene Kim and Park, \{Se Jin\} and Park, \{Jai Hyung\} and Hong, \{Seok Jin\} and Hong, \{Hyun Pyo\}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

month = jun,

day = "5",

doi = "10.1016/j.cca.2015.03.043",

language = "English",

volume = "446",

pages = "111--116",

journal = "Clinica Chimica Acta",

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TY - JOUR

T1 - A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men

AU - Park, Sung Keun

AU - Chun, Hyejin

AU - Ryoo, Jae Hong

AU - Lee, Sang Wha

AU - Lee, Hong Soo

AU - Shim, Kyung Won

AU - Cho, Choo Yon

AU - Ryu, Dong Ryeol

AU - Ko, Taeg Su

AU - Kim, Eugene

AU - Park, Se Jin

AU - Park, Jai Hyung

AU - Hong, Seok Jin

AU - Hong, Hyun Pyo

PY - 2015/6/5

Y1 - 2015/6/5

N2 - Background: Despite the previous studies showing the relationship between microalbuminuria and insulin resistance, longitudinal effect of insulin resistance on development of microalbuminuria is not clearly identified in non-diabetic population. Methods: One thousand six hundred three non-diabetic Korean men without microalbuminuria in 2005 had been followed up for the development of microalbuminuria until 2010. Microalbuminuria was evaluated by urine-albumin creatinine ration, and insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Cox proportional hazards model was used to estimate the risk for microalbuminuria according to the tertile of HOMA-IR. Results: During 5465.8 person-y of average follow-up, microalbuminuria developed in 76 (4.7%) participants. Incidence of microalbuminuria increased in proportion to the level of HOMA-IR (tertile 1: 3.0%, tertile 2: 4.1%, tertile 3: 7.1%, P<. 0.001). When the 1st tertile of HOMA-IR was set as reference, hazard ratios and 95% confidence interval were 1.15 (0.56-2.35) and 2.07 (1.05-4.09) for those in the 2nd and 3rd tertiles of HOMA-IR, even after adjusting multiple covariates, respectively (. P for linear trend. =. 0.054). Conclusions: Increased insulin resistance was a predictor of microalbuminuria in Korean men.

AB - Background: Despite the previous studies showing the relationship between microalbuminuria and insulin resistance, longitudinal effect of insulin resistance on development of microalbuminuria is not clearly identified in non-diabetic population. Methods: One thousand six hundred three non-diabetic Korean men without microalbuminuria in 2005 had been followed up for the development of microalbuminuria until 2010. Microalbuminuria was evaluated by urine-albumin creatinine ration, and insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Cox proportional hazards model was used to estimate the risk for microalbuminuria according to the tertile of HOMA-IR. Results: During 5465.8 person-y of average follow-up, microalbuminuria developed in 76 (4.7%) participants. Incidence of microalbuminuria increased in proportion to the level of HOMA-IR (tertile 1: 3.0%, tertile 2: 4.1%, tertile 3: 7.1%, P<. 0.001). When the 1st tertile of HOMA-IR was set as reference, hazard ratios and 95% confidence interval were 1.15 (0.56-2.35) and 2.07 (1.05-4.09) for those in the 2nd and 3rd tertiles of HOMA-IR, even after adjusting multiple covariates, respectively (. P for linear trend. =. 0.054). Conclusions: Increased insulin resistance was a predictor of microalbuminuria in Korean men.

KW - HOMA-IR

KW - Insulin resistance

KW - Microalbuminuria

UR - https://www.scopus.com/pages/publications/84928730018

U2 - 10.1016/j.cca.2015.03.043

DO - 10.1016/j.cca.2015.03.043

M3 - Article

C2 - 25896961

AN - SCOPUS:84928730018

SN - 0009-8981

VL - 446

SP - 111

EP - 116

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

ER -

A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men

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Keywords

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