A case of von Hippel-Lindau Disease with colorectal adenocarcinoma, renal cell carcinoma and hemangioblastomas

Su Jin Heo; Choong kun Lee; Kyu Yeon Hahn; Gyuri Kim; Hyuk Hur; Sung Hoon Choi; Kyung Seok Han; Arthur Cho; Minkyu Jung

doi:10.4143/crt.2014.299

A case of von Hippel-Lindau Disease with colorectal adenocarcinoma, renal cell carcinoma and hemangioblastomas

Su Jin Heo, Choong kun Lee, Kyu Yeon Hahn, Gyuri Kim, Hyuk Hur, Sung Hoon Choi, Kyung Seok Han, Arthur Cho, Minkyu Jung

Yonsei University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

von Hippel-Lindau (VHL) disease is an autosomal dominant inherited tumor syndrome associated with mutations of the VHL tumor suppressor gene located on chromosome 3p25. The loss of functional VHL protein contributes to tumorigenesis. This condition is characterized by development of benign and malignant tumors in the central nervous system (CNS) and the internal organs, including kidney, adrenal gland, and pancreas. We herein describe the case of a 74-year-old man carrying the VHL gene mutation who was affected by simultaneous colorectal adenocarcinoma, renal clear cell carcinoma, and hemangioblastomas of CNS.

Original language	English
Pages (from-to)	409-414
Number of pages	6
Journal	Cancer Research and Treatment
Volume	48
Issue number	1
DOIs	https://doi.org/10.4143/crt.2014.299
State	Published - 2016
Externally published	Yes

Keywords

Colorectal neoplasm
Hemangioblastoma
Renal cell carcinoma
von Hippel-Lindau disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4143/crt.2014.299

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abstract = "von Hippel-Lindau (VHL) disease is an autosomal dominant inherited tumor syndrome associated with mutations of the VHL tumor suppressor gene located on chromosome 3p25. The loss of functional VHL protein contributes to tumorigenesis. This condition is characterized by development of benign and malignant tumors in the central nervous system (CNS) and the internal organs, including kidney, adrenal gland, and pancreas. We herein describe the case of a 74-year-old man carrying the VHL gene mutation who was affected by simultaneous colorectal adenocarcinoma, renal clear cell carcinoma, and hemangioblastomas of CNS.",

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AU - Heo, Su Jin

AU - Lee, Choong kun

AU - Hahn, Kyu Yeon

AU - Kim, Gyuri

AU - Hur, Hyuk

AU - Choi, Sung Hoon

AU - Han, Kyung Seok

AU - Cho, Arthur

AU - Jung, Minkyu

PY - 2016

Y1 - 2016

N2 - von Hippel-Lindau (VHL) disease is an autosomal dominant inherited tumor syndrome associated with mutations of the VHL tumor suppressor gene located on chromosome 3p25. The loss of functional VHL protein contributes to tumorigenesis. This condition is characterized by development of benign and malignant tumors in the central nervous system (CNS) and the internal organs, including kidney, adrenal gland, and pancreas. We herein describe the case of a 74-year-old man carrying the VHL gene mutation who was affected by simultaneous colorectal adenocarcinoma, renal clear cell carcinoma, and hemangioblastomas of CNS.

AB - von Hippel-Lindau (VHL) disease is an autosomal dominant inherited tumor syndrome associated with mutations of the VHL tumor suppressor gene located on chromosome 3p25. The loss of functional VHL protein contributes to tumorigenesis. This condition is characterized by development of benign and malignant tumors in the central nervous system (CNS) and the internal organs, including kidney, adrenal gland, and pancreas. We herein describe the case of a 74-year-old man carrying the VHL gene mutation who was affected by simultaneous colorectal adenocarcinoma, renal clear cell carcinoma, and hemangioblastomas of CNS.

KW - Colorectal neoplasm

KW - Hemangioblastoma

KW - Renal cell carcinoma

KW - von Hippel-Lindau disease

UR - https://www.scopus.com/pages/publications/84957535144

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M3 - Article

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AN - SCOPUS:84957535144

SN - 1598-2998

VL - 48

SP - 409

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JO - Cancer Research and Treatment

JF - Cancer Research and Treatment

IS - 1

ER -

A case of von Hippel-Lindau Disease with colorectal adenocarcinoma, renal cell carcinoma and hemangioblastomas

Abstract

Keywords

UN SDGs

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