A case of cutaneous leukocytoclastic vasculitis associated with granulocyte colony-stimulating factor: An unusual presentation

Dokyoung Yoon; Hyun Jeong Byun; Se Jin Oh; Ji Hye Park; Dong Youn Lee

doi:10.5021/AD.2020.32.2.164

A case of cutaneous leukocytoclastic vasculitis associated with granulocyte colony-stimulating factor: An unusual presentation

Dokyoung Yoon, Hyun Jeong Byun, Se Jin Oh, Ji Hye Park, Dong Youn Lee

Department of Dermatology

Sungkyunkwan University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Drug-induced vasculitis is an inflammation of small-sized blood vessel caused by the use of drugs. It accounts for approximately 10% of acute cutaneous vasculitis. Propylthiouracil, hydralazine, and allopurinol have been widely known as causative agents. The most common clinical feature of drug-induced vasculitis is palpable purpura on lower extremities. A 66-year-old Korean female presented with erythematous nodules on upper chest and back. She had been on medication for multiple myeloma. Laboratory results showed neutropenia. After a single injection of filgrastim (recombinant granulocyte colony-stimulating factor), she developed cutaneous lesions with concurrent increase in absolute neutrophil count. A skin biopsy revealed leukocytoclastic vasculitis. After discontinuation of filgrastim injection, her skin lesions disappeared spontaneously.

Original language	English
Pages (from-to)	164-167
Number of pages	4
Journal	Annals of Dermatology
Volume	32
Issue number	2
DOIs	https://doi.org/10.5021/AD.2020.32.2.164
State	Published - 1 Apr 2020

Keywords

Cutaneous
Cutaneous small vessel
Granulocyte colonystimulating factor
Skin
Vasculitis

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title = "A case of cutaneous leukocytoclastic vasculitis associated with granulocyte colony-stimulating factor: An unusual presentation",

abstract = "Drug-induced vasculitis is an inflammation of small-sized blood vessel caused by the use of drugs. It accounts for approximately 10\% of acute cutaneous vasculitis. Propylthiouracil, hydralazine, and allopurinol have been widely known as causative agents. The most common clinical feature of drug-induced vasculitis is palpable purpura on lower extremities. A 66-year-old Korean female presented with erythematous nodules on upper chest and back. She had been on medication for multiple myeloma. Laboratory results showed neutropenia. After a single injection of filgrastim (recombinant granulocyte colony-stimulating factor), she developed cutaneous lesions with concurrent increase in absolute neutrophil count. A skin biopsy revealed leukocytoclastic vasculitis. After discontinuation of filgrastim injection, her skin lesions disappeared spontaneously.",

keywords = "Cutaneous, Cutaneous small vessel, Granulocyte colonystimulating factor, Skin, Vasculitis",

author = "Dokyoung Yoon and Byun, \{Hyun Jeong\} and Oh, \{Se Jin\} and Park, \{Ji Hye\} and Lee, \{Dong Youn\}",

note = "Publisher Copyright: Copyright {\textcopyright} The Korean Dermatological Association and The Korean Society for Investigative Dermatology.",

year = "2020",

month = apr,

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doi = "10.5021/AD.2020.32.2.164",

language = "English",

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journal = "Annals of Dermatology",

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T1 - A case of cutaneous leukocytoclastic vasculitis associated with granulocyte colony-stimulating factor

T2 - An unusual presentation

AU - Yoon, Dokyoung

AU - Byun, Hyun Jeong

AU - Oh, Se Jin

AU - Park, Ji Hye

AU - Lee, Dong Youn

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Drug-induced vasculitis is an inflammation of small-sized blood vessel caused by the use of drugs. It accounts for approximately 10% of acute cutaneous vasculitis. Propylthiouracil, hydralazine, and allopurinol have been widely known as causative agents. The most common clinical feature of drug-induced vasculitis is palpable purpura on lower extremities. A 66-year-old Korean female presented with erythematous nodules on upper chest and back. She had been on medication for multiple myeloma. Laboratory results showed neutropenia. After a single injection of filgrastim (recombinant granulocyte colony-stimulating factor), she developed cutaneous lesions with concurrent increase in absolute neutrophil count. A skin biopsy revealed leukocytoclastic vasculitis. After discontinuation of filgrastim injection, her skin lesions disappeared spontaneously.

AB - Drug-induced vasculitis is an inflammation of small-sized blood vessel caused by the use of drugs. It accounts for approximately 10% of acute cutaneous vasculitis. Propylthiouracil, hydralazine, and allopurinol have been widely known as causative agents. The most common clinical feature of drug-induced vasculitis is palpable purpura on lower extremities. A 66-year-old Korean female presented with erythematous nodules on upper chest and back. She had been on medication for multiple myeloma. Laboratory results showed neutropenia. After a single injection of filgrastim (recombinant granulocyte colony-stimulating factor), she developed cutaneous lesions with concurrent increase in absolute neutrophil count. A skin biopsy revealed leukocytoclastic vasculitis. After discontinuation of filgrastim injection, her skin lesions disappeared spontaneously.

KW - Cutaneous

KW - Cutaneous small vessel

KW - Granulocyte colonystimulating factor

KW - Skin

KW - Vasculitis

UR - https://www.scopus.com/pages/publications/85086116644

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DO - 10.5021/AD.2020.32.2.164

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JO - Annals of Dermatology

JF - Annals of Dermatology

IS - 2

ER -

A case of cutaneous leukocytoclastic vasculitis associated with granulocyte colony-stimulating factor: An unusual presentation

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Keywords

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