코르티솔 검출을 위한 MIP 전기화학 센서

Cortisol is a stress hormone secreted by the adrenal gland and plays an important role in blood sugar production, maintenance of basal metabolism, inhibition of liposynthesis, anti-inflammatory, anti-allergic action, and stress response. Interest and importance in stress management have increased significantly since the COVID-19 pandemic. Therefore, it is possible to develop a healthcare system that diagnoses diseases such as chronic stress and adrenal disorders by detecting cortisol quickly and sensitively. MIP was introduced to detect cortisol effectively. To create an optimal MIP sensor, production variables such as monomer concentration, electropolymerization cycle, pH, monomer:target ratio, removal technology, and reaction time were optimized. The optimized cortisol MIP sensor showed excellent sensitivity ranging from 0.1-100 nM. Through selectivity experiments using NIP sensors, the specific binding ability of MIP sensors to cortisol was verified and distinguished from other steroid hormones. This study laid the foundation for the development of MIP research using O-PD.