γ-Cyclodextrin-phenylacetic acid mesh as a drug trap

Hyeong Sup Yu; Jae Min Lee; Yu Seok Youn; Kyung Taek Oh; Kun Na; Eun Seong Lee

doi:10.1016/j.carbpol.2017.12.078

γ-Cyclodextrin-phenylacetic acid mesh as a drug trap

Hyeong Sup Yu, Jae Min Lee, Yu Seok Youn, Kyung Taek Oh, Kun Na, Eun Seong Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

In this study, we developed a nanoporous biodegradable mesh, bioinspired by the spider web, which is prepared via electrospinning using γ-cyclodextrin (γ-CD) conjugated with phenylacetic acid (PA), named γ-CDP. The resulting γ-CDP has a microfibrous or microspherical shape and contains drug trap meshlike γ-CD pores. These γ-CDP micromeshes (microspheres or microfibers) enable efficient drug capture and drug transport into deep γ-CDP nanocompartments or out of the γ-CDP web, resulting in a driving domain for a 4-week drug release. When used to deliver chemotherapeutic agents to xenografted tumors, the γ-CDP implants caused nearly complete tumor regression for 4 weeks after single administration. This strategy of a drug trap biodegradable mesh (with low density) will make drug containers uniquely attractive for the development of therapeutic implants and functional biomedical devices.

Original language	English
Pages (from-to)	390-400
Number of pages	11
Journal	Carbohydrate Polymers
Volume	184
DOIs	https://doi.org/10.1016/j.carbpol.2017.12.078
State	Published - 15 Mar 2018

Keywords

Biodegradable implant
Drug trap mesh
Electrospinning
Nanoporous sphere/fiber

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10.1016/j.carbpol.2017.12.078

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title = "γ-Cyclodextrin-phenylacetic acid mesh as a drug trap",

abstract = "In this study, we developed a nanoporous biodegradable mesh, bioinspired by the spider web, which is prepared via electrospinning using γ-cyclodextrin (γ-CD) conjugated with phenylacetic acid (PA), named γ-CDP. The resulting γ-CDP has a microfibrous or microspherical shape and contains drug trap meshlike γ-CD pores. These γ-CDP micromeshes (microspheres or microfibers) enable efficient drug capture and drug transport into deep γ-CDP nanocompartments or out of the γ-CDP web, resulting in a driving domain for a 4-week drug release. When used to deliver chemotherapeutic agents to xenografted tumors, the γ-CDP implants caused nearly complete tumor regression for 4 weeks after single administration. This strategy of a drug trap biodegradable mesh (with low density) will make drug containers uniquely attractive for the development of therapeutic implants and functional biomedical devices.",

keywords = "Biodegradable implant, Drug trap mesh, Electrospinning, Nanoporous sphere/fiber",

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doi = "10.1016/j.carbpol.2017.12.078",

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T1 - γ-Cyclodextrin-phenylacetic acid mesh as a drug trap

AU - Yu, Hyeong Sup

AU - Lee, Jae Min

AU - Youn, Yu Seok

AU - Oh, Kyung Taek

AU - Na, Kun

AU - Lee, Eun Seong

PY - 2018/3/15

Y1 - 2018/3/15

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AB - In this study, we developed a nanoporous biodegradable mesh, bioinspired by the spider web, which is prepared via electrospinning using γ-cyclodextrin (γ-CD) conjugated with phenylacetic acid (PA), named γ-CDP. The resulting γ-CDP has a microfibrous or microspherical shape and contains drug trap meshlike γ-CD pores. These γ-CDP micromeshes (microspheres or microfibers) enable efficient drug capture and drug transport into deep γ-CDP nanocompartments or out of the γ-CDP web, resulting in a driving domain for a 4-week drug release. When used to deliver chemotherapeutic agents to xenografted tumors, the γ-CDP implants caused nearly complete tumor regression for 4 weeks after single administration. This strategy of a drug trap biodegradable mesh (with low density) will make drug containers uniquely attractive for the development of therapeutic implants and functional biomedical devices.

KW - Biodegradable implant

KW - Drug trap mesh

KW - Electrospinning

KW - Nanoporous sphere/fiber

UR - https://www.scopus.com/pages/publications/85040008262

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DO - 10.1016/j.carbpol.2017.12.078

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AN - SCOPUS:85040008262

SN - 0144-8617

VL - 184

SP - 390

EP - 400

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

ER -

γ-Cyclodextrin-phenylacetic acid mesh as a drug trap

Abstract

Keywords

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